Based on the findings of a study conducted on mice, researchers have developed a treatment capable of reversing memory loss associated with Alzheimer’s disease.

a new treatment able to reverse the effects of memory loss associated with Alzheimer’s disease. This research, co-led by two brothers, Dr Arne Ittner and Professor Lars Ittner, from the Center for Dementia Research at Macquarie University, builds on their work started in 2016. This study then involved gene therapy breakthrough using an enzyme naturally present in the brain known as p38gamma. The two scientists carried out their study on mice. Through their analyzes, they found that when the enzyme p38gamma was activated, it could modify a protein that prevents symptoms of Alzheimer’s disease from developing. Results published in the journal Acta Neuropathologica.

Through their work, they also discovered that this enzyme can improve and restore memory in mice suffering from an already advanced stage of the disease. What’s more, their results also suggest that gene therapy may be effective in relieving other forms of dementia. “When we set out to develop this gene therapy, we expected it to stop the progression of dementia, but we didn’t expect it to reverse it. This approach completely reversed the memory loss already installed at the start of therapy.“, Sums up Professor Lars Ittner, director of the dementia research center at Macquarie University.” Data-reactid = “24”> Alzheimer’s disease plagues the daily lives of nearly three million French people. , but also their relatives directly affected. Today, France has around 900,000 patients. While a research team is working on the development of a test for the early detection of the disease, other scientists are work to develop a treatment.

In Australia, researchers at Macquarie University have discovered a new treatment capable of reversing the effects of memory loss associated with Alzheimer’s disease. This research, co-led by two brothers, Dr Arne Ittner and Professor Lars Ittner, from the Center for Dementia Research at Macquarie University, builds on their work started in 2016. This study then involved gene therapy breakthrough using an enzyme naturally present in the brain known as p38gamma. The two scientists carried out their study on mice. Through their analyzes, they discovered that when the enzyme p38gamma was activated, it could modify a protein that prevents symptoms of Alzheimer’s disease from developing. Results published in the journal Acta Neuropathologica.

Through their work, they also discovered that this enzyme can improve and restore memory in mice suffering from an already advanced stage of the disease. What’s more, their results also suggest that gene therapy may be effective in relieving other forms of dementia. “When we set out to develop this gene therapy, we expected it to stop the progression of dementia, but we didn’t expect it to reverse it. This approach completely reversed the memory loss already installed at the start of therapy.”, Summarizes Professor Lars Ittner, director of the Center for Dementia Research at Macquarie University.

A new therapeutic avenue